Synthesis, Characterization and Antimicrobial activity of 2- Amino-1,3-benzothiazole, Schiff bases and Azo dyes of 2-Amino- 1,3-benzothiazole
نویسندگان
چکیده
2-Amino-1,3-benzothiazole was synthesized and schiff bases were prepared by reacting a series of aromatic aldehydes with 2-amino-1,3-benzothiazole to form a number of potentially biologically active compounds. Azo dyes of 2-amino-1,3-benzothiazole were synthesized by reacting various aromatic amines , substituted amines and phenols. The structures of 2-amino-1,3-benzothiazole, Schiff bases and azo dyes were confirmed by using FT-IR, HNMR, Mass, UV, spectroscopic technique. The dyeing ability of azo dyes was checked by applying azo dyes on various fabrics. The tiltle compounds were also tested against representatives of gram-positive and gram negative bacteria by agar diffusion method. Ampicillin was used as positive control. Key-words : Benzothiazole , aldehydes, schiffs bases, azo dyes, antimicrobial
منابع مشابه
Synthesis and Antimicrobial Evaluation of some novel Schiff bases derived from Benzothiazole derivative
In an attempt to find out a new class of antimicrobial agents new series of Benzylidine-2imino-1,3-benzothiazole and other related products containing benzothiazole moiety were prepared. The synthesis was carried out by condensation of different aromatic aldehydes with benzothiazole derivative using different procedures. The synthesised compounds were characterized and evaluated for antimicrobi...
متن کاملSynthesis of New Pyridine Based 4-Thiazolidinones Incorporated Benzothiazoles and Evaluation of Their Antimicrobial Activity
Substituted Schiff bases (hydrazones) 5a-j have been prepared from the starting material 2-chloro pyridine-3-carboxylic acid 1 by a sequence of reactions like reaction with 2-amino-6-nitro benzothiazole (Ullamann condensation), thionyl chloride, hydrazine hydrate and different aromatic aldehydes. On cyclocondensation of 5a-j with thioglycolic acid in dry 1,4-dioxane furnished desired compounds ...
متن کامل2-Substituted Hydrazino-6-Fluoro-1,3-Benzothiazole: Synthesis and Characterization of new Novel AntimicrobiaL Agents
A series of novel 2-substituted hydrazino-6-fluoro-1,3-benzothiazole derivatives were synthesized by synthesizing the 2-hydrazino-6-fluorobenzothiazole and refluxing of this with different substituted acetophenones. The synthesized compounds were evaluated for their possible antimicrobial activity. The structures of few representative compounds were elucidated by IR and NMR. For present work ef...
متن کاملSynthesis and Anti-bacterial Screening of Some Novel Fused Imino Pyrimido Benzothiazole and Its Schiff’s Bases
Benzotiazole and pyrimidine have been reported to act as effective pharmacophores. However, much less work as been carried out on these heterocycles fused with each other. In the present study, we report the synthesis of a series of 8-chloro-3(phenylcarbonoimidoyl)-10a-H-pyrimido [2,1-b][1,3]benzothiazole-2-thiol. This series was synthesized by the reaction of 8-chloro-2-sulfanyl-10a-H-pyrimido...
متن کاملSynthesis, Characterisation and Anti-inflammatory Activity of Some 2-amino Benzothiazole Derivatives
A series of some novel 2-amino benzothiazole derivatives were synthesized and evaluated for antiinflammatory activity. The titled compounds were synthesized from the substituted aromatic amines through the intermediate substituted 1-phenylthiourea oxidation by bromine water in acidic medium. The purity of the synthesized compounds were judged by their C, H and N analysis and the structure was a...
متن کامل